Thursday, February 27, 2020

9:45 - 11:00am European Charcot Foundation Symposium
11:15am - 1:45pm NAIMS-IMSVISUAL Joint Symposium
2:00 - 2:10pm Opening Address
Jeffrey A. Cohen, Cleveland Clinic; Tanuja Chitnis, Brigham and Women's Hospital, Harvard University;  Alexandre Prat, Université de Montréal
2:10 - 3:20pm Kenneth P. Johnson Memorial Lecture
Peter Calabresi, Johns Hopkins University
 3:20-3:50pm Break
 3:50-5:10pm SESSION 1 - Emerging Concepts in MS
Chairs: Fiona Costello, University of Calgary; Myla Goldman, University of Virginia; Adil Harroud, McGill University

Theme: Highlighting cutting edge studies that inform our understanding of the pathogenic mechanisms in MS, introduce novel measures to capture disease activity and advance treatment options for affected individuals. This session will be comprised of platform presentations by Young Investigators selected from submitted abstracts.
  3:50-4:00pm Depression in MS is Associated with Worsening Neuroperformance, Relapses, and New Brain Lesions
Jenny Feng, Cleveland Clinic
  4:00-4:10pm Human Glial Progenitor Cells Effectively Remyelinate the Demyelinated Adult Brain
John Mariani, University of Rochester
  4:10-4:20pm Measuring Demyelination, Axonal Loss and Inflammation After Acute and Subacute Injury to Human Spinal Cord with Quantitative Magnetic Resonance Imaging and Histopathology
Sarah Morris, University of British Columbia
  4:20-4:30pm A Combined ScRNAseq and 21-color Flow Cytometry Approach to Characterize Peripheral Immune Cells in Multiple Sclerosis
Rose-Marie Rebillard, Université of Montréal
  4:30-4:40pm The Power of Single Cell Technologies; From T Cell Receptor to Antigen(s) in Multiple Sclerosis
Naresha Saligrama, Washington University in St. Louis
  4:40-4:50pm Encephalomyelitis Reveals a Critical Role for Wnt/β-catenin Signaling in Pathogenic Neoangiogenesis
Sanjid Shahriar, Columbia University
  4:50-5:00pm Baseline Cerebral Metabolism Predicts Fatigue and Cognition in Multiple Sclerosis Patients
Kathryn West, University of Texas at Dallas
  5:00-5:10pm Nulliparity or Early Menopause are Associated with Earlier Evolution of Progressive Multiple Sclerosis in Women
Burcu Zeydan, Mayo Clinic
5:15-6:00pm National Multiple Sclerosis Society (NMSS) Barancik Award Presentation and Talk
Francisco J. Quintana, Brigham and Women's Hospital, Harvard University
6:00-8:00pm Poster Session 1 / Opening Networking Event
6:00-6:30pm Faculty Office Hours
with Kenneth P. Johnson Memorial Lecturer, Dr. Peter Calabresi

Friday, February 28, 2020

7:00-8:15am Industry Supported CME Satellite Breakfast Symposium
Clinical Updates on Immune-Directed Therapies for MS: Expert Insights & Real-World Evidence 
This CME activity is jointly provided by Letters & Sciences and Postgraduate Institute for Medicine. This independent Industry Supported Satellite Symposium is supported by an educational grant from EMD Serono.
8:00-8:30am Breakfast
8:30-11:30am SESSION 2 - Network Analysis Applied to MS
Chairs: Philip De Jager, Columbia University; Nathalie Arbour, Université de Montréal; Stephanie Zandee, Université de Montréal

Theme: To explore network theory and analysis applied to cellular and genomic datasets in MS to enhance the understanding of MS pathobiology. Talks will also explore data-mining tools to identify novel therapeutic targets for MS; as well as the impact of social networks on MS outcomes.
  8:30-8:35am Session Introduction
  8:35-9:00am Network Theory as it Applies to MS
Sergio Baranzini, University of California, San Francisco
  9:00-9:25am Applied Epigenomics for Understanding MS Pathogenesis
Maja Jagodic, University of California, San Francisco
  9:25-9:55am Break
  9:55-10:20am Data-mining for Predicting Therapeutic Response in MS
Bibi Bielekova, National Institutes of Health
  10:20-10:45am Social Networks in MS and Related Diseases
Amar Dhand, Brigham and Women's Hospital, Harvard University
  10:45-11:00am Panel Discussion
11:00am-1:00pm Poster Session 2 / Lunch
11:00-11:30am Faculty Office Hours
with Session 2 Speakers
1:00-3:30pm SESSION 3 - Immune Cell Networks in MS
Chairs: Benjamin M. Segal, Ohio State University; Gregory Wu, Washington University at St. Louis; Anne-Katrin Pröbstel, University of California, San Francisco

Theme: This session will explore novel interactions between peripheral immune cell subsets in MS, and its impact on therapeutics.
  1:00-1:05pm Session Introduction
  1:05-1:30pm Lymphocyte-myeloid Cell Networks in MS
Estelle Bettelli, University of Washington
  1:30-1:55pm Imaging of the Immune Cell-endothelial Cell Network During CNS Repair
Dorian McGavern, National Institutes of Health, National Institute of Neurological Disorders and Stroke
  1:55-2:25pm Break
  2:25-2:50pm Lymphocyte-meningeal Mediated CNS Inflammation in MS
Zsuzsanna Fabry, University of Wisconsin-Madison
  2:50-3:15pm Review of the Impact of Current Therapeutics on Immune Cell Networks
Frauke Zipp, Universitätsmedizin Mainz
  3:15-3:30pm Panel Discussion
3:30-3:45pm Break
3:45-5:15pm Cutting Edge Developments
Chairs: Tiffany Braley, University of Michigan; Susan Gauthier, Cornell University; Manu Rangachari, University of Laval
  3:45-4:00pm Microbiome and Immune Analysis in AQP4 NMO
Scott Zamvil, University of California, San Francisco
  4:00-4:15pm Epigenetic Changes in the Brain and Immune Cells of MS Patients
Patrizia Casaccia, The City University of New York
 4:15-5:15pm Groundbreaking Abstracts
  4:15-4:25pm Melanoma Cell Adhesion Molecule (MCAM) on Blood-Brain Barrier Endothelium Contributes to Neuroinflammation by Promoting T Lymphocyte Recruitment
Marc Charabati, Université of Montréal
The N-MOmentum Trial of Inebilizumab for Neuromyelitis Optica Spectrum Disorder: Randomized Controlled Period and Long-term Openlabel Extension
Bruce Cree, University of California, San Francisco
  4:35-4:45pm Analysis of Intrathecally Synthesized Inflammatory Mediators Identifies Unique Dynamic Networks Associated with Disease Activity in MS
Francesca Gilli, Dartmouth-Hitchcock Medical Center
  4:45-4:55pm Modulatory Potential of the Th2 Cytokine Interleukin-13 on the Blood-Brain Barrier and on Immune Cells in MS
Chloé Hoornaert, Université de Montréal
  4:55-5:05pm Diffusely Abnormal White Matter Transforming into Focal White Matter Lesions Associates with Progression in Secondary Progressive MS
Josefina Maranzano, McGill University
  5:05-5:15pm Metabolic Abnormalities Associated with Phase Rims in Progressive MS
Ian Tagge, McGill University
5:15-5:30pm Awards Presentation
5:30-6:30pm Awards Reception
5:30-6:00pm Faculty Office Hours
with Session 3 Speakers
6:00-6:30pm Faculty Office Hours
with Cutting Edge Speakers
6:45-8:00pm Industry Supported CME Satellite Dinner Symposium*
Update on the Pathogenesis, Diagnosis, and Treatment of Neuromyelitis Optica Spectrum Disorder
This CME activity is provided by Med Learning Group. This independent Industry Supported Satellite Symposium is supported by an educational grant from Genentech.
 8:00-10:00pm Conversations, Cocktails & Crepes
Grandview Public Market Networking Event
Keep the conversations going, enjoy a locally crafted cocktail and experience custom made crepes at this one of a kind ACTRIMS networking event! Located in the Warehouse District, this communal market is a collection of open-space eateries in a restored warehouse with an artisan, local feel and different eclectic food concepts. Guests may enjoy dinner first on their own with a 10% discount to an eatery option of their choosing, then join ACTRIMS for networking over cocktails and dessert crepes in two private event space locations within the warehouse. Space is limited. COST: $20.00 includes cocktails and dessert.

Saturday, February 29, 2020

6:30-7:45am Industry Supported CME Satellite Breakfast Symposium*
A Virtual Reality Look at Diagnosis, Treatment and Patient Engagement in the Care of MS: Insights from the Experts
This CME activity is provided by Med Learning Group. This independent Industry Supported Satellite Symposium is supported by educational grants from Biogen and Genentech, a member of the Roche Group.
7:00-8:00am Breakfast
8:00-10:00am SESSION 4 - CNS Cellular Networks in MS
Chairs: V. Wee Yong, University of Calgary; Catherine Larochelle, Université de Montréal; Kirsten Scarlett Evonuk, Cleveland Clinic

Theme: This session will focus on imaging and immunological mechanisms of CNS cells including microglia and astrocytes and the impact of this work on therapeutic development.
  8:00-8:05am Session Introduction
  8:05-8:30am Microglia-cytokine Axis to Modulate Synaptic Connectivity: Potential Applications to MS
Dorothy Schafer, University of Massachusetts
  8:30-8:55am Neuronal and Glial Cell Imaging in MS
Tarun Sighal, Brigham and Women's Hospital, Harvard University
  8:50-9:20am Neuronal Network Dysfunction in the Inflamed Gray Matter
Martin Kerschensteiner, Ludwig Maximilians University of Munich
  9:20-9:45am Glial Cell Related Therapeutics
Veronique Miron, The University of Edinburgh
  9:45-10:00am Panel Discussion
10:00-10:15am Break
10:15am-12:15pm SESSION 5 - Neural-anatomical Networks
Chairs: Daniel Reich, National Institutes of Health, National Institute of Neurological Disorders and Stroke; Maria Rocca, Scientific Institute Ospedale San Raffaele; Christina Azevedo, University of Southern California

Theme: This session will explore novel neuroimaging tools to assess correlates of clinical and cognitive dysfunction in MS, and CNS processes of neurodegeneration, remyelination and repair.
  10:15-10:20am Session Introduction
  10:20-10:45am Neuronal Hubs in MS
Eric Klawiter, Harvard University
  10:45-11:10am fMRI Correlates of Cognitive Dysfunction in MS
Nancy Sicotte, Cedars Sinai Medical Center
  11:10-11:35am Imaging Biomarkers of Remyelination and Repair
Jiwon Oh, University of Toronto
  11:35am-12:00pm Imaging of Neural Plasticity in MS
Peter Stys, University of Calgary
  12:00-12:15pm Panel Discussion
12:15-1:35pm Lunch
12:30-1:00pm Faculty Office Hours
with Session 4 Speakers
1:00-1:30pm Faculty Office Hours
with Session 5 Speakers
12:20-1:35pm Industry Supported CME Satellite Lunch Symposium*
Navigating the Evolving Management Paradigm Across Multiple Sclerosis Phenotypes in the Age of Potential Prognostic and Predictive Biomarkers
This CME activity is jointly provided by PeerView Institute for Medical Education (PVI) and Medical Learning Institute, Inc. This independent Industry Supported Satellite Symposium is supported by educational grants from Novartis Pharmaceuticals Corporation and Sanofi Genzyme.
1:45-3:45pm SESSION 6 - Microbial Networks and Interactions with the CNS
Chairs: Emmanuelle Waubant, University of California, San Francisco; Stephanie Tankou, Mount Sinai; Marc Charabati, Université de Montréal

Theme: To explore the evolving field of microbial influences on the immune and CNS in MS, as well as novel therapeutic strategies targeting microbiota.
  1:45-1:50pm Session Introduction
  1:50-2:15pm The Gut Microbiota and MS with a Focus on Pediatric MS
Helen Tremlett, University of British Columbia
  2:15-2:40pm Microbiota and Immune System Networks in the Periphery
Jennifer Gommerman, University of Toronto
  2:40-3:05pm Potential for Microbiome as a Therapeutic Target
Howard Weiner, Harvard University
  3:05-3:30pm Caloric Restriction and Dietary Interventions in MS
Ellen Mowry, Johns Hopkins University
  3:30-3:45pm Panel Discussion
3:45-3:55pm Closing Remarks
Jeffrey A. Cohen, Cleveland Clinic
3:55-4:25pm Faculty Office Hours
with Session 6 Speakers

*Independent Industry Supported CME Satellite Symposia are not included in the ACTRIMS Forum 2020 accredited program.