ACTRIMS FORUM 2019 PROGRAM

Thursday, February 28, 2019

11:00am - 12:15pm Industry Supported CME Satellite Symposium*
Clinical Advances in Immune-directed Therapies: Expert Insights and Case Challenges in MS
This CME activity is jointly provided by Letters & Sciences and Postgraduate Institute for Medicine. This activity is supported by an educational grant from EMD Serono.
12:30 - 1:45pm IMSVISUAL Symposium
2:00pm - 2:10pm Opening Address
Jack Antel, McGill University; Tanuja Chitnis, Brigham & Woman's Hospital, Harvard; Alexandre Prat, Université de Montréal
2:10pm - 3:30pm SESSION 1 - Emerging Concepts in MS
Chairs: Catherine Larochelle, Université de Montreal; Benjamin Segal, University of Michigan

Theme: Highlighting cutting edge studies that inform our understanding of the pathogenic mechanisms in MS, introduce novel measures to capture disease activity, and advance treatment options for affected individuals. This session will be comprised of platform presentations by Young Investigators selected from submitted abstracts. There will be eight 10 minute talks, each consisting of eight minute presentations and two minute Q&A.
2:10pm - 2:20pm The "Central Vein Sign" in Inflammatory Demyelination: The Role of Fibrillar Collagen Type I
Martina Absinta, National Institutes of Health, National Institutes of Neurological Disorders and Stroke
2:20pm - 2:30pm Accelerated Cord Atrophy Precedes Conversion to Secondary Progressive Disease in Relapsing Multiple Sclerosis
Antje Bischof, University of California, San Francisco
2:30pm - 2:40pm NLRX1 Inhibits Early Stages of CNS Inflammation and Prevents the Onset of EAE
Marjan Gharagozloo, University of Sherbrooke
2:40pm - 2:50pm Parental Imprinting of X Chromosome Genes: Effects on Autoimmunity
Lisa Golden, University of California, Los Angeles
2:50pm - 3:00pm Leukocyte Telomere Length is Associated with Disability Progression in Multiple Sclerosis Independent of Chronological Age
Kristen Krysko, University of California, San Francisco
3:00pm - 3:10pm Cerebrospinal Fluid Biomarkers Link Toxic Astrogliosis and Microglial Activation to Multiple Sclerosis Severity
Ruturaj Masvekar, National Institutes of Health, National Institutes of Allergy & Infectious Diseases
3:10pm - 3:20pm Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation Via IL10
Olga Rojas, University of Toronto
3:20pm - 3:30pm Single-Cell Genomics Reveals Spatial and Stage-Associated Diversity in Multiple Sclerosis
Lucas Schirmer, University of Heidelberg
3:30pm - 4:00pm BREAK
3:35pm - 3:55pm Industry Supported Non-CME Product Theater**
Disease Progression: Changing How We Think About MS

This non-CME activity is provided by Genentech.
4:00pm - 5:15pm Kenneth P. Johnson Memorial Lecture
Bedside to Bench to Bedside in MS

Rhonda Voskuhl, University of California, Los Angeles
5:15pm - 6:00pm National Multiple Sclerosis Society (NMSS) Barancik Award Presentation and Talk
Katerina Akassoglou, University of California, San Francisco
6:00pm - 8:00pm Poster Session 1 / Opening Networking Event

Friday, MARCH 1, 2019

6:30am - 7:00am NAIMS Refreshments
7:00am - 8:00am NAIMS Symposium
8:30am - 11:30am SESSION 2 - Precision Medicine for MS
Chairs: Tanuja Chitnis, Brigham & Woman's Hospital, Harvard University; Alexandre Prat, Université de Montréal

Theme: Precision diagnostic tools are utilized in several areas of medicine and lessons learned may be applied to MS. There are emerging biomarkers distinguishing MS from similarly appearing diseases. Imaging and molecular biomarkers that distinguish MS from other diseases will further enhance diagnostic criteria.
8:30am - 8:40am Opening Comments by Session Chairs
8:40am - 9:05am From Basic Science to Precision Medicine in Oncology: Lessons Learned and a Guide for MS
John Frederick de Groot, MD Anderson
9:05am - 9:30am From Basic Science to Precision Medicine in Rheumatology: Lessons Learned and a Guide for MS
Timothy Niewold, New York University
9:30am - 10:00am BREAK
10:00am - 10:25am Precision Medicine in the MS Clinic: Current State and New Biological Tools
Gavin Giovannoni, Blizard Institute
10:25am - 10:50am Precision Medicine in the MS Clinic: Selecting the Right Patient for the Right Treatment
Mark Freedman, University of Ottawa
10:50am - 11:15am Panel Discussion
11:15am - 1:00pm Poster Session 2 / Lunch
1:00pm - 3:45pm SESSION 3 - Precision Diagnosis of MS
Chairs: Jiwon Oh, University of Toronto; Phil de Jager, Columbia University

Theme: There are emerging pathological, genetic and immunological biomarkers including antigen specific responses that characterize and differentiate MS from other similar neuroimmunological diseases.
1:00pm - 1:10pm Opening Comments by Session Chairs
1:10pm - 1:35pm Genetic and Gene Expression Signatures for MS Diagnosis
Nikolaos Patsopoulos, Brigham and Women's Hospital, Harvard University
1:35pm - 2:00pm Can the B Cell and T Cell Profiles Be Used for Precision Diagnosis and Treatment of Demyelinating Diseases?
Jeffrey Bennett, University of Colorado
2:00pm - 2:30pm BREAK
2:30pm - 2:55pm Spectrum of MS Disease Course (Mild, Severe, MSSS)
Ilya Kister, New York University
2:55pm - 3:20pm New Imaging Approaches for Precision Diagnosis of MS
Andrew Solomon, University of Vermont
3:20pm - 3:45pm Panel Discussion
3:45pm - 4:00pm BREAK
4:00pm - 5:00pm Cutting Edge Developments
Chairs: Joan Goverman, University of Washington; Craig Moore, Memorial University of Newfoundland
4:00pm - 4:10pm Mass Spec Imaging of MS Lesion
Jennifer Gommerman, University of Toronto
4:10pm - 4:20pm Flow Cytometry of Ex Vivo MS Brain
Tess Dhaeze, Université de Montréal
4:20pm - 4:30pm Nuclear RNAseq of MS Samples
Francisco Javier Quintana, Brigham and Women's Hospital, Harvard University
4:30pm - 4:40pm Primary Analysis of a Randomized Phase II Study to Evaluate the Efficacy and Safety of Evobrutinib, a BTK Inhibitor, in Patients with Relapsing MS
Xavier Montalban, University of Toronto, Hospital Universitari Vall d'Hebron
4:40pm - 4:50pm The Transient Receptor Potential Vanilloid 4 (TRPV4) Channels Are Expressed By Microglia and Modulate Neuroinflammation
Gregory Wu, Washington University in St. Louis
4:50pm - 5:00pm Associations Between Myelin Damage in the Cervical Spinal Cord and Disability in Relapsing and Progressive Multiple Sclerosis
Lisa Eunyoung Lee, University of British Columbia
5:00pm - 5:10pm Comprehensive Assessments in Clinic Using Technology-Enabled Neuroperformance Testing, Patient Reported Outcomes, and Advanced MRI
Laura Baldassari, Cleveland Clinic
5:10pm - 5:20pm Fast Sub-Millimeter Whole-Brain Magnetic Resonance Imaging of Novel Biomarkers for Multiple Sclerosis
Pascal Sati, National Institutes of Health, National Institutes of Neurological Disorders and Stroke
5:20pm - 5:30pm Prediction of Disability and Treatment Response from Radiomic Features: A Machine Learning Analysis from the Combirx Multi-Center Cohort
Kareem Wahid, The University of Texas Health Science Center at Houston
5:30pm - 6:30pm Awards Reception
6:45pm Busses Depart for Experience Dallas Dine Around
Experience Dallas as a local, from a local! This unique tour combines sightseeing and delicious food experiences into one fun-packed evening including a city bus tour and foodie excursion. Space for this tour is limited and advanced registration is required.

Saturday, March 2, 2019

6:30am - 7:45am Industry Supported CME Satellite Symposium*
An Interactive, Case-Based Discussion: Interpreting the Therapeutic Landscape in Multiple Sclerosis
This CME activity is provided by Physicians' Education Resource, LLC. This activity is jointly supported by educational grants from Sanofi Genzyme and Celgene Corporation.
8:00am - 9:50am SESSION 4 - MS Disease Course Endophenotypes
Chairs: Orhun H. Kantarci, Mayo Clinic; Helen Tremlett, University of British Columbia

Theme: There is significant heterogeneity in the MS disease course amongst patients. This session will discuss MS disease endophenotypes and associations with key demographic features.
8:00am - 8:10am Opening Comments by Session Chairs
8:10am - 8:30am Immunobiological and Radiological Markers of MS Endophenotypes
Roberta Magliozzi, University of Verona
8:30am - 8:50am Retinal Imaging for MS Diagnosis and Monitoring
Shiv Saidha, Johns Hopkins University
8:50am - 9:10am Effect of Race and Ethnicity on MS Presentation and Disease Course
Lilyana Amezcua, University of Southern California
9:10am - 9:30am Role of Comorbidities in the Course of MS: Diagnostic and Treatment Implications
Ruth Ann Marrie, University of Manitoba
9:30am - 9:50am Panel Discussion
9:50 - 10:05am Break
10:05 - 11:50am SESSION 5 - Biomarker Measures of MS Disease Course
Chairs: Sergio Baranzini, University of California, San Francisco; Anne Cross, Washington University in St. Louis

Theme: Biomarkers which correlate or predict MS disease course may be of value in guiding management. This session will review emerging biomarkers and novel technologies applicable to MS.
10:05am - 10:15am Opening Comments by Session Chairs
10:15am - 10:40am Role of NFL and Other Biomarkers in MS Diagnosis and Disease Course
David Leppert, University of Basel
10:40am - 11:05am Metabolomic Profiling in MS
Pavan Bhargava, Johns Hopkins University
11:05am - 11:30am miRNA and Exosome Profiling in MS
Marcin Mycko, University of Lodz
11:30am - 11:50am Panel Discussion
11:05am - 1:05pm LUNCH
11:50am - 1:05pm Industry Supported CME Satellite Lunch Symposium*
Advanced Strategies to Improve Outcomes and Reduce Disability in Patients with Multiple Sclerosis
This CME activity is provided by AcademicCME. This activity is supported by an educational grant from Novartis Pharmaceuticals.
1:05 - 2:55pm SESSION 6 - Algorithms Informing Precision Management of MS
Chairs: Xavier Montalban, University of Toronto, Hospital Universitari Vall d'Hebron; Jennifer Graves, University of California, San Francisco

Theme: Informed algorithms and predictors of optimized treatment and management can enhance patient outcomes. This session will discuss emerging technologies and algorithms to optimize MS patient management.
1:05pm - 1:15pm Opening Comments by Session Chairs
1:15pm - 1:35pm Applications of Network Science to Medical Challenges
Italo Faria do Valle, Northeastern University
1:35pm - 1:55pm Biosensors for Measuring Disease Activity in MS and Neurological Disorders
Dina Katabi, Massachusetts Institute of Technology
1:55pm - 2:15pm How Can Large MRI Datasets Impact Precision Medicine in MS
Tal Arbel, McGill University
2:15pm - 2:35pm Artificial Intelligence to Advance the Diagnosis and Treatment of Neurological Diseases
Ming Jack Po, Google
2:35pm - 2:55pm Panel Discussion
2:55pm - 3:05pm Closing Remarks
Jeffrey Cohen, Cleveland Clinic
3:15pm - 4:30pm Industry Supported CME Satellite Symposium*
A Virtual Reality Learning Experience - Concepts of Disease-Modifying Therapy: Initiating and Maintaining Personalized Treatment in Multiple Sclerosis
This CME activity is provided by Med Learning Group. This activity is jointly supported by educational grants from Biogen, Celgene Corporation, Genentech, and Sanofi Genzyme.

*Independent Industry Supported CME Satellite Symposia are not included in the formal ACTRIMS Forum 2019 accredited program.
**Independent Industry Supported non-CME Product Theaters are not included in the formal ACTRIMS Forum 2019 accredited program.